Swift, strandwise translocation

Strandwise translocation of a DNA glycosylase on undamaged DNA.

Base excision repair of genotoxic nucleobase lesions in the genome is critically dependent upon the ability of DNA glycosylases to locate rare sites of damage embedded in a vast excess of undamaged DNA, using only thermal energy to fuel the search process. Considerable interest surrounds the question of how DNA glycosylases translocate efficiently along DNA while maintaining their vigilance for...

Spectroscopic SWIFT

INTRODUCTION Often the ability to obtain chemical-shift information is needed and advantageous in MRI. In addition to providing chemical information, the acquired spectral dimension can also be used to reduce image blur resulting from frequency shifts of all types. This work describes a new 3D and 4D spectroscopic technique involving an intrinsic frequency dimension. The method is based on an o...

SWIFT adoption challenges perSpecTIve

Inositol phospholipids: Translocation, translocation, translocation …

The pleckstrin homology (PH) domains of a number of proteins have been found to interact in vitro with inositol phospholipids; recent experiments show that these interactions may be important in directing protein translocation to specific parts of the cell following stimulus-induced lipid breakdown or synthesis.

Swift Regular Expression Matching

Queries involving Regular Expressions (RegEx) have a wide range of applications including document stores, bioinformatics and information retrieval. However, efficiently executing RegEx queries over large datasets remains a challenging task. Data scans do not scale well with input size; however, existing techniques that avoid data scans — referred to as “black-box” approaches — offer little or ...